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  • Title: Mechanism of the onset of puberty, with special reference to the dynamics of the hypothalamic gonadotropin releasing factor and pituitary gonadotropin.
    Author: Suzuki M, Kawagoe S, Hiroi M.
    Journal: Acta Med Biol (Niigata); 1971 Jun; 19(1):1-25. PubMed ID: 4936226.
    Abstract:
    In vivo and in vitro studies of the dynamics of hypothalamic FSH-RF, LH-RF, PIF, and anterior pituitary FSH, LH, and prolactin during the process of sexual maturation were carried out in female Wistar-starin rats. Around the time of vaginal opening there was a wide fluctuation of hormonal values. The peak of FSH content in the anterior pituitary was on Day 25 after birth, LH peaked on Day 40, and prolactin on Day 45. Addition of crude HE (hypothalamic extract) of 20-45 day old female rats to the incubation fluid of anterior pituitary glands resulted in a rise of FSH and LH activity in the culture fluid. The greatest increase of FSH activity was seen on the addition of HE of 20-day-old rats. LH increased most on hte addition of HE in 35-day-old rats and prolactin decreased on the addition of HE in 45-day-old rats. The relationship between anterior pituitary FSH, LH, and prolactin contents and hypothalamic RF and IF is suggested.
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