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  • Title: Plasma and central nervous system kinetics of gamma-hydroxybutyrate.
    Author: Shumate JS, Snead OC.
    Journal: Res Commun Chem Pathol Pharmacol; 1979 Aug; 25(2):241-56. PubMed ID: 493714.
    Abstract:
    Sodium gamma-hydroxybutyrate was administered to dogs in dosages of 200 to 1000 mg per kg with continuous EEG and temperature monitoring. Based on these studies, pulsed doses of 500 mg/kg of GHB were given and timed serum, cerebrospinal fluid (CSF) and brain samples obtained. In addition a group of animals were sacrificed 60 minutes after GHB administration and the regional distribution of GHB determined. The CSF kinetics of GBH suggests a passive diffusionof GHB into CSF but brain concentration peaked very early. Highest concentrations of GHB were found in cortical white matter with lower concentrations in subcortical areas.
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