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  • Title: Phase resetting and annihilation of pacemaker activity in cardiac tissue.
    Author: Jalife J, Antzelevitch C.
    Journal: Science; 1979 Nov 09; 206(4419):695-7. PubMed ID: 493975.
    Abstract:
    Spontaneous rhythmic activity in isolated cardiac pacemaker cells can be terminated by a brief, subthreshold, depolarizing or hyperpolarizing perturbation of the proper magnitude applied at a specific point in the pacemaker cycle. Evidence is provided in support of a topological theory of the existence of a "singular" point in cardiac oscillators.
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