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  • Title: L-asparaginase induced immunosuppression: inhibition of bone marrow derived antibody precursor cells.
    Author: Friedman H.
    Journal: Science; 1971 Oct 08; 174(4005):139-41. PubMed ID: 4940962.
    Abstract:
    The cooperation between bone marrow and thymus cells in restoring the hemolytic antibody response to sheep erythrocytes in immunosuppressed recipients was markedly inhibited when donor mice were treated with L-asparaginase, a known inhibitor of lymphocyte function. The marrow cell population was shown to be a major target for the immunosuppressive activity of asparaginase, since thymus cells from enzyme-treated animals interacted with marrow cells from normal animals to generate immunocompetent cells.
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