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Title: Abnormal gangliosides in Tay-Sachs disease, Niemann-Pick's disease, and gargoylism. Author: Booth DA, Goodwin H, Cumings JN. Journal: J Lipid Res; 1966 May; 7(3):337-40. PubMed ID: 4959256. Abstract: The molar ratios of N-acetyl neuraminic acid, hexose, hexosamine, and sphingosine have been determined for the abnormal ganglioside in Tay-Sachs disease that was previously detected as a fast-moving band in thin-layer chromatography, and in two abnormal fast-moving bands of gangliosides from the cortex and white matter of the brain in cases of gargoylism and Niemann-Pick's disease. The fastest-moving ganglioside band in these two conditions contains neither hexosamine nor glucose.[Abstract] [Full Text] [Related] [New Search]