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  • Title: Acute granulomatous response produced in mice by trehalose-6,6-dimycolate.
    Author: Bekierkunst A.
    Journal: J Bacteriol; 1968 Oct; 96(4):958-61. PubMed ID: 4971895.
    Abstract:
    Trehalose-6,6-dimycolate, a toxic lipid derived from tubercle bacilli, injected intravenously into mice in 10% emulsions of Bayol F caused a three- to fourfold increase in the weights of lungs compared with those of mice injected with emulsions of Bayol F alone or emulsions of Wax D. This change is due to a heavy infiltration of the lungs with granulocytes and large numbers of macrophages, with formation in some of the infiltrates of round foci, resembling granulomas.
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