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  • Title: [Activation of prekallikrein from human blood serum by different activators].
    Author: Iarovaia GA, Dotsenko VL, Krizhevskaia IuV, Morozova NA, Orekhovich VN.
    Journal: Biokhimiia; 1979 Jul; 44(7):1279-85. PubMed ID: 497275.
    Abstract:
    It was shown that the activated Hageman factor and its active fragment convert a greater amount of prekallikrein into kallikrein than is observed under the effects of trypsin and kallikrein. The latter two enzymes convert from 30 to 60% of the Hageman factor-activated prekallikrein and its active fragment. A possible existence of two prekallikrein forms is discussed. A mechanism of interaction between individual components of the kininogenase system and their activators is discussed.
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