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  • Title: Material for the study ofvariation in the Malayan Langat virus (TP-21 strain).
    Author: Il'enko VI, Platonov VG, Prozorova IN, Smorodincev AA.
    Journal: Bull World Health Organ; 1968; 39(3):419-24. PubMed ID: 4973556.
    Abstract:
    The lack of genetic uniformity of the Malayan Langat virus, TP-21 strain isolated from Ixodes granulatus ticks in Malaya, was demonstrated.Increased pathogenicity of the virus for white mice and rhesus monkeys after passage through chick-embryo fibroblast cultures at temperatures of 36 degrees C and 40 degrees C is due to the selection of the pathogenic virus particles which are always present in the initial brain-tissue suspension of the TP-21 Langat strain.The frequency of the occurrence of pathogenic clones and their selection rate was studied in relation to the conditions of cultivation. A study was also made of the genetic stability and basic biological properties of pathogenic and non-pathogenic clones of the Langat virus.
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