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  • Title: Autoimmune alterations in the neurohypophysis of rabbits immunized against vasopressin.
    Author: Cau P, Rougon-Rapuzzi G.
    Journal: Brain Res; 1979 Nov 16; 177(2):265-71. PubMed ID: 497831.
    Abstract:
    Rabbits immunized against vasopressin developed clinical signs of diabetes insipidus persisting for up to two months after the last boost. Ultrastructural and immunocytochemical studies of the neurohypophysis demonstrated autoimmune alterations: infiltration by immune cells and extracellular deposits of immunoglobulins. No alterations were observed in the hypothalamic nuclei synthesizing vasopressin nor in hormone-target cells of the kidney. Immunization against vasopressin may provide the first example of an autoimmune disease in the hypothalamo-neurohypophysial system.
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