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  • Title: Symposium on portal hypertension and its complications: current management. Preoperative assessment and predictors of encephalopathy.
    Author: Huet PM, Marleau D, Viallet A, Duguay L, Tanguay S, Lavoie P.
    Journal: Can J Surg; 1979 Nov; 22(6):545-8. PubMed ID: 497928.
    Abstract:
    None of the preoperative predictors of encephalopathy proposed so far to evaluate the risk of portacaval shunting in cirrhotic patients has been of value. The authors have found, in preliminary studies, that measurement of the hepatic extraction of indocyanine green (ICG), which correlates highly with the "functional" portal blood supply, could be of prognostic value: cirrhotic patients with a near-normal value for ICG extraction often have encephalopathy after portacaval shunting whereas those with a low ICG extraction value seldom have encephalopathy. These preliminary data suggest that cirrhotic patients with markedly decreased ICG extraction have a lesser risk of encephalopathy since their portal blood supply is already shunted away from hepatocytes before the operation because of anatomic changes in the liver microcirculation.
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