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  • Title: Effect of metastatic cancer on platelet monoamine oxidase activity and serotonin metabolism.
    Author: Feldman JM.
    Journal: Cancer; 1979 Nov; 44(5):1751-6. PubMed ID: 498046.
    Abstract:
    Platelet monoamine oxidase (MAO) activity and urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA), serotonin, tyramine and tryptamine were measured in patients with a variety of metastatic cancers and in healthy control subjects. The patients with cancer had higher platelet MAO activity and lower urinary excretion of 5-HIAA, sertonin and tyramine than the healthy subjects. The urinary tryptamine excretion was not significantly different in the two groups. At the present time it is unclear if the alterations in platelet MAO activity and monoamine excretion are casually related.
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