These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: A correlation between estrogen sulfotransferase levels and estrogen receptor status in human primary breast carcinoma.
    Author: Adams JB, Pewnim T, Chandra DP, Archibald L, Foo MS.
    Journal: Cancer Res; 1979 Dec; 39(12):5124-6. PubMed ID: 498139.
    Abstract:
    Estrogen sulfotransferase (EC 2.8.2.4) activity and estrogen receptor levels were measured in 32 human primary breast cancer cytosol preparations. Two types of tumors were identified: type 1, in which estrogen sulfotransferase levels were low (less than 40 pmol 17 beta-estradiol 3-sulfate formed per mg protein per 2 hr) and were independent of [35S]adenosine 3'-phosphate 5'-phosphosulfate production from [35S]sulfate and adenosine triphosphate, and type 2, in which estrogen sulfotransferase levels ranged from 50 to 200 pmol 17 beta-estradiol 3-sulfate per mg protein per 2 hr and were correlated with [35S]adenosine 3'-phosphate 5'-phosphosulfate formation (r = 0.70; p less than 0.005). In type 1 tumors, 11 of 16 were estrogen receptor negative; in type 2 tumors, 2 of 16 were receptor negative. Estrogen sulfotransferase levels in receptor-negative tumors were significantly lower than the levels in receptor-positive tumors (p = 0.025). Results of a study of estrogen Rc receptors in 32 primary human breast cancer cytosol preparations are presented. Tritiated sulfate activation to tritiated adenosine 3'-phosphate 5'-phosphosulfate and subsequent formation of tritiated estrogen sulfotranferase levels was assessed in these preparations. 2 groups of tumors were identified: a low estrogen sulfurylation which was predominantly Rc negative, and a high estrogen sulfurylation with almost exclusive Rc -positivity. In the 1st type of tumor, in which estrogen sulfotranferase levels were low (40 pmol of 17beta-estradiol 3-sulfate formed/mg of protein/2 hours) and were independent of tritiated adenosine 3'-phosphate 5'-phosphosulfate production from tritiated sulfate and adenosine triphosphate, and in the 2nd type of tumor, in which estrogen sulfotransferase levels ranged from 50-200 pmol of 17 beta-estradiol 3-sulfate/mg of protein/2 hours, there was a correlation between the 2 in terms of tritiated adenosine 3'-phosphate 5'-phosphosulfate formation (P.005). 11 of 16 of the 1st type of tumor were estrogen receptor negative, whereas 2 of 16 of the 2nd tumor type were receptor negative. In receptor-negative tumors, the estrogen sulfotransferasse levels were significantly lower than those in receptor-positive tumors (rho=.025).
    [Abstract] [Full Text] [Related] [New Search]