These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Lack of proportionality between rate of cell division and induction of tumors in carcinogen-exposed regenerating livers.
    Author: Becker FF.
    Journal: Cancer Res; 1979 Dec; 39(12):5177-8. PubMed ID: 498144.
    Abstract:
    Although a single pulse of dimethylnitrosamine administered during the regenerative response of liver subsequent to 70% hepatectomy resulted in more primary hepatocellular carcinomas in treated livers than in controls, the response was not proportionate to the level of cell division. Further, the use of 55-g male Sprague-Dawley rats that displayed an extremely active regenerative response did not significantly shorten the lag period before the appearance of tumors. Of additional interest was the finding that the post-S period might be even more susceptible to dimethylnitrosamine than the S phase was. These results support the suggestion that many aspects of the interaction between carcinogens and dividing cells and the requirement for subsequent events for the development remain unclear.
    [Abstract] [Full Text] [Related] [New Search]