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  • Title: Bacterical activity of rabbit serum containing immnoconglutinin.
    Author: Mittal KR, Ingram DG.
    Journal: Immunology; 1969 Nov; 17(5):677-84. PubMed ID: 4982022.
    Abstract:
    The bactericidal activity of normal rabbit serum and of rabbit serum containing immunoconglutinin was studied with three Gram-negative and two Gram-positive bacteria and a yeast. With all micro-organisms tested, the immunoconglutinin sera had significantly higher bactericidal activities than normal sera. Absorption of natural homologous antibodies from normal serum led to inactivation of the bactericidal activity while absorption of natural heterologous antibodies resulted in a marked decrease in bactericidal activity. Similar absorptions of immunoconglutinin serum were much less effective in reducing the bactericidal activity. It is suggested that natural antibody and immunoconglutinin, in the presence of complement, act synergistically to increase bactericidal activity. Both normal and immunoconglutinin sera that had complement destroyed or absorbed failed to show any bactericidal activity. Attempts to absorb immunoconglutinin without destroying complement activity were unsuccessful. The physiological role of immunoconglutinin in increasing the resistance of man and animals to infectious diseases is discussed.
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