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  • Title: Myeloperoxidase: contribution to the microbicidal activity of intact leukocytes.
    Author: Klebanoff SJ.
    Journal: Science; 1970 Sep 11; 169(3950):1095-7. PubMed ID: 4988715.
    Abstract:
    Azide and, to a lesser extent, cyanide inhibit the microbicidal activity of myeloperoxidase and of intact normal leukocytes, but they have little or no effect on peroxidase-negative leukocytes. The contribution of the azide-sensitive (peroxidase-dependent?) systems to the total microbicidal activity of normal leukocytes is considerable. The azide-insensitive antimicrobial systems are more highly developed in peroxidase-negative leukocytes than in normal leukocytes, thus suggesting an adaptation.
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