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Title: [Possibilities of treatment reduction in Hodgkin's disease (author's transl)]. Author: Teillet F, Delbrück H, Bayle-Weisgerber C, Andrieu JM, Clot P. Journal: Dtsch Med Wochenschr; 1979 Oct 05; 104(40):1405-9. PubMed ID: 498955. Abstract: Exploratory laparotomy with splenectomy was performed before or after multiple chemotherapy in 182 patients with clinically localised Hodgkin's disease in clinical stages IB, II3A, IIB, III A and III B. There was a 50% probability of clinically not diagnosed infradiaphragmatic involvement in patients with clinically localised stage IB, II B or II3A. Restaging was necessary in 20% of patients with clinical stage III, because infradiphragmatic involvement was histologically not demonstrable. Infradiaphragmatic involvement occurred in 12% of patients who had received six chemotherapy cycles according to the MOPP scheme, before exploratory splenectomy. When chemotherapy produced complete clinical remission, only 2.7% patients had any infradiaphragmatic involvements. Exploratory laparotomy with splenectomy is not required, therefore, in such patients.[Abstract] [Full Text] [Related] [New Search]