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  • Title: The interaction of normal lymphocytes and cells from lymphoid cell lines. I. The nature of the activation process.
    Author: Hardy DA, Knight S, Ling NR.
    Journal: Immunology; 1970 Aug; 19(2):329-42. PubMed ID: 4990403.
    Abstract:
    Human peripheral lymphocytes from all donors tested were mitotically activated when cultured in the presence of X-irradiated cells from continuously cultivated lymphoid cell lines (LCL). X-irradiated cells from LCL originating from normal individuals were effective as well as those of Burkitt's tumour origin and cells from LCL reported to be free of herpes-like virus were as effective as those reported to contain virus. The activation was of much greater intensity than the normal mixed lymphocyte reaction but occurred over a similar culture period. The reaction occurred only under conditions permitting direct cell contact between the two populations of cells. Most stimulation was obtained with viable X-irradiated LCL cells. Disrupted LCL cells were ineffective.
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