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  • Title: Serum-alpha2-macroglobulin, transferrin, albumin, and IgG levels in preeclampsia.
    Author: Horne CH, Howie PW, Goudie RB.
    Journal: J Clin Pathol; 1970 Sep; 23(6):514-6. PubMed ID: 4991000.
    Abstract:
    A radial immunodiffusion technique has been used to measure levels of four serum proteins in preeclampsia with or without proteinuria and in normal pregnant and non-pregnant controls. In preeclampsia unaccompanied by proteinuria, albumin and transferrin levels are similar to those found in the normal pregnant controls, but there are significant falls in alpha(2)-macroglobulin and IgG. When preeclampsia is accompanied by proteinuria there is a marked fall in albumin and an increase in alpha(2)-macroglobulin. Since alpha(2)-macroglobulin has antiplasmin activity it is possible that increased levels of this protein in preeclampsia accompanied by proteinuria contribute to the intravascular coagulation which has been described in this disorder.
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