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  • Title: Sub-units of the first complement component in immunologic deficiency syndromes: independence of Cls and Clq.
    Author: Stroud RM, Nagaki K, Pickering RJ, Gewurz H, Good RA, Cooper MD.
    Journal: Clin Exp Immunol; 1970 Aug; 7(2):133-7. PubMed ID: 4991118.
    Abstract:
    Normal concentrations of C1 esterase, C1s, have been found in nineteen individuals with a variety of immunologic deficiency syndromes. C1q levels are markedly low in patients with lymphopenic hypogammaglobulinaemia. The lack of correlation of serum concentrations of C1s with C1q in several patients suggests a separate mode of synthesis or catabolism for these C1 subunits. Furthermore, the extreme C1q deficiency in lymphopenic hypogammaglobulinaemic patients may play a role in their serious prognosis; however the normal C1s concentrations would allow some complement mediated functions.
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