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  • Title: Sporulation in Bacillus subtilis. Correlation of biochemical events with morphological changes in asporogenous mutants.
    Author: Waites WM, Kay D, Dawes IW, Wood DA, Warren SC, Mandelstam J.
    Journal: Biochem J; 1970 Jul; 118(4):667-76. PubMed ID: 4991477.
    Abstract:
    A comparison was made of morphological changes and successive, mainly biochemical, marker events for sporulation in 14 asporogenous mutants. The morphological and biochemical sequences are linked so that arrested development in one is accompanied by corresponding effects in the other. Thus mutants that fail to produce both protease and antibiotic do not progress beyond stage 0, formation of alkaline phosphatase appears to be associated with the transition from stage II to stage III and glucose dehydrogenase with that from stage III to stage IV. Stage II mutants may produce ;pygmy' cells or other bizarre cell-division forms. The biochemical sequence is dependent in the sense that if the occurrence of any one event is blocked that of all the succeeding events is also blocked. This has implications for biochemical models that have been proposed to explain the temporal sequence observed in spore development.
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