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  • Title: The effect of 1-phenylalanine mustard on anti-globulin antibodies in multiple myeloma.
    Author: Waller M, Moon JH, Irby R, Toone EC.
    Journal: Clin Exp Immunol; 1971 Jan; 8(1):91-100. PubMed ID: 4993198.
    Abstract:
    An immunochemical and serological study of a patient with rheumatoid arthritis who developed multiple myeloma and was treated with 1-phenylalanine mustard showed a striking difference in the effect of this drug on the rapidly dividing cells, as opposed to the resting plasma cells. The titres of anti-globulin antibodies such as the IgG serum agglutinators and the IgM rheumatoid factors were little altered although the IgG myeloma spike has disappeared following therapy. Fractionation of two different serum samples from 1966 and 1970 showed the IgG paraprotein to be serologically inactive for anti-globulin activity. This paraprotein was also characterized by producing only a single IgG precipitin line with horse anti-human whole serum antibody while the normal IgG globulins always showed a double line.
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