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  • Title: Tolmetin and G-6-PD erythrocyte deficiency: research in vitro.
    Author: Passiu G, Piras MG, Perpignano G, Ibba G, Carcassi U.
    Journal: J Int Med Res; 1979; 7(5):351-3. PubMed ID: 499642.
    Abstract:
    In thirty-two patients, divided into four groups: normal, G-6-PD deficient, beta-thalaxemic heterozygote and carriers of both anomalies, the variations in erythrocyte GSH were studied after incubation with APH and a non-steroidal anti-inflammatory drug: tolmetin sodium. The results obtained show a considerable fall in GSH after incubation with APH above all in the G-6-PD deficient patients and in the carriers of both anomalies. On the other hand, after incubation with the drug under examination there were no significant variations in the erythrocyte GSH.
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