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  • Title: Response of plasma somatostatin-like immunoreactivity to the administration of alloxan in dogs.
    Author: Schusdziarra V, Harris V, Unger R.
    Journal: Horm Metab Res; 1979 Aug; 11(8):457-9. PubMed ID: 499995.
    Abstract:
    The present study was designed to examine the effects of intravenously injected alloxan (75 mg/kg) upon plasma somatostatin-like immunoreactivity (SLI), glucagon (IRG), insulin (IRI) and glucose levels in 6 dogs. Within 2 hours of the injection of alloxan, SLI and IRI levels decreased significantly below their respective baselines, while IRG and plasma glucose concentrations increased. At 8 hours SLI levels had increased significantly by 55 pg/ml, together with a rise in IRI and a decrease in IRG and glucose concentrations. After 24 hours, marked hyperglycemia and hyperglucagonemia had developed whereas SLI levels were not different from preinjection values.
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