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  • Title: [Comparative studies on effects of estrogens and progesterone on the contractility of isolated uterine horns of rats].
    Author: Czarnocki L, Wiciński R.
    Journal: Pol Tyg Lek; 1972 Feb 14; 27(7):267-9. PubMed ID: 5011604.
    Abstract:
    The effect of estrogens on the myometrial contractility of 70 isolated uterine horns of rats was investigated; 40 of the rats had been treated with progesterone and 30 with estrogen. Contractions were recorded isotonically in solutions with extracellular potassium concentration of 2.5 to 40 mM. The contractility of the myometrium of rats treated with estrogens was observed to be similar to the optimum contractility during labor, with the characteristic high amplitude of tension, low initial tension, and good coordination of contractions. The contractility of the uterine horns treated with progesterone was almost 1/2 lower and showed worse coordination of contractions. The difference between progesterone and estrogen is expressed through the quantitatively and qualitatively different influences on the motor function of the uterus.
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