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  • Title: Action of L- -methyldopa-hydrazine on the blood pressure of patients receiving levodopa.
    Author: Calne DB, Petrie A, Rao S, Reid JL, Vakil SD.
    Journal: Br J Pharmacol; 1972 Jan; 44(1):162-4. PubMed ID: 5015036.
    Abstract:
    The blood pressure and pulse rate have been compared in a 'double blind, cross over' study involving twenty patients with idiopathic Parkinsonism receiving maximum tolerated dosage of levodopa with and without an extracerebral decarboxylase inhibitor, L-alpha-methyldopahydrazine. The supine and erect systolic pressures were significantly higher and the erect pulse rate significantly lower during administration of L-alpha-methyldopahydrazine. The implications of these observations are discussed.
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