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  • Title: IUD-induced delay in postcoital rise in 20 -hydroxypregn-4-en-3-one in the female rabbit.
    Author: Makino T, Yoshinaga K, Greep RO.
    Journal: Proc Soc Exp Biol Med; 1972 Apr; 139(4):1162-5. PubMed ID: 5023310.
    Abstract:
    The influence of a silicone rubber tube IUD upon the serum 20a-hydroxypregn-4-en-3-one (2Oa-Oh-p) was examined in a group of female rabbits. These results were compared with those from rabbits who received the same tests but did not have the IUD. All animals were mated after insertion of the IUD. Beginning one hour after mating, blood samples were drawn every five hours and were examined for 2Oa-Oh-p) concentration. Then each animal was opened by a ventrolateral incision and the number of ovarian stigmata were counted at 12 and 24 hours after the incision. In the control group the highest levels of 2Oa-Oh-p were detected at 1.67 plus or minus 1.03 hours. In the animals with the IUD, the highest peak of 2Oa-Oh-p occurred at 4.20 plus or minus 1.10 hours. In both groups the lowest value was at 9 hours. The difference between groups was significant at p less than .005. The number of stigmata on the ovary did not differ significantly. It appears that the IUD causes a delay in the post-coital rise in 2Oa-Oh-p in this reflex-ovulating species.
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