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  • Title: Effect of immunochemotherapy on lymphocyte response of patients with gastrointestinal cancer.
    Author: Mashiba H, Yoshinaga H, Matsunaga K, Gojobori M, Furusawa M.
    Journal: J Surg Oncol; 1979; 12(3):275-9. PubMed ID: 502567.
    Abstract:
    Patients with gastrointestinal cancer were treated with 5-fluorouracil (5-FU) in combination with a streptococcal preparation, OK-432, or without OK-432 before operation, and lymphocyte response to PHA was examined. Oral administration of 5-FU with or without intramuscular injection of OK-432 did not affect the response. However, treatment with cytostatic drugs in combination with OK-432 markedly augmented the lymphocyte response to PHA, but the cytotoxic activity of lymphocytes was not elevated.
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