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  • Title: 5"-Amino-3',4',5"-trideoxybutirosin A, a new semisynthetic aminoglycoside antibiotic.
    Author: Woo PW.
    Journal: J Antibiot (Tokyo); 1975 Jul; 28(7):522-9. PubMed ID: 50312.
    Abstract:
    5"-Amino-3',4',5"-trideoxybutirosin A (IX) was synthesized through a reaction series starting from 5"-amino-5"-deoxybutirosin A (Ic), the key step being the treatment of its tetra-O-acetylpentakis-N-((phenylemthoxy)carbonyl)-3',4'-bis-O-(methylsulfonyl) derivative (VI) with zince-sodium iodide. Compound IX inhibits enhanced antibacterial activities, including strains of Pseudomonas aeruginosa and Escherichia coli which are highly resistant to Ic, butirosin or gentamicin.
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