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  • Title: Trophic regulation of acetylcholine sensitivity of muscle: effect of electrical stimulation.
    Author: Drachman DB, Witzke F.
    Journal: Science; 1972 May 05; 176(4034):514-6. PubMed ID: 5032352.
    Abstract:
    Denervation of skeletal muscle results in a spread of acetylcholine sensitivity over the entire surface membrane. Electrical stimulation, programmed to mimic the normal activity pattern, was applied continuously to the denervated rat diaphragm in vivo. After 4 days, the acetylcholine sensitivity was far less in the stimulated diaphragms than in denervated controls. Muscle activity may account for "neurotrophic" regulation of the acetylcholine sensitivity.
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