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  • Title: Carbonic anhydrase and bone remodeling: sulfonamide inhibition of bone resorption in organ culture.
    Author: Minkin C, Jennings JM.
    Journal: Science; 1972 Jun 02; 176(4038):1031-3. PubMed ID: 5033181.
    Abstract:
    Five sulfonamide inhibitors of carbonic anhydrase inhibited parathyroid hormone-induced resorption of bone in organ culture. The relative activities of the sulfonamides as resorption inhibitors were such as to suggest the presence of a functional carbonic anhydrase system in bone linked to the mechanism of bone resorption.
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