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  • Title: [Anti-edema activity of injectable Venoruton in abdominal surgery].
    Author: De Anna D, Liboni A, Paoli M, Pollinzi V, Malin L, Mannella P, Ambroso G, Oberhauser V.
    Journal: Minerva Chir; 1979 Oct 31; 34(20):1377-92. PubMed ID: 503345.
    Abstract:
    The anti-oedema activity of an injectable drug (HR; active principle: 0-(beta-hydroxyethyl)-rutoside) was assessed in 60 gastric extrahepatic bile duct, and large intestine surgery patients (30 being used as controls). Gastroscopy (with biopsy), gastroduodenoscopy, colonoscopy (with biopsy) and radiological examination were usually performed on the 5th and 10th post-operative days. The drug showed significant therapeutic effects: rapid resolution of oedema, especially at the sutures, leading to early cicatrisation, canalisation and the prevention of dehiscence. Finally, duration of hospitalisation was less than in the untreated cases. The gastroscopic, radiographic and biopsy findings are considered to have shown clear evidence of the drug's action against oedema formation.
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