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  • Title: Specific triiodothyronine binding sites in the anterior pituitary of the rat.
    Author: Schadlow AR, Surks MI, Schwartz HL, Oppenheimer JH.
    Journal: Science; 1972 Jun 16; 176(4040):1252-4. PubMed ID: 5033645.
    Abstract:
    Studies with L-[(125)l] triiodothyronine and L-[(125)l] thyroxine, and with equilibrium dialysis of plasma proteins indicate that rat pituitary binds L-triiodothyronine 9.8 times as strongly as it does L-thyroxine. Injection of even small doses of nonradioactive L-triiodothyronine reduces the pituitary/ plasma ratio of radioactive L-triiodothyronine, an indication of the existence of pituitary binding sites with a limited capacity for L-triiodothyronine. Limited capacity binding sites for L-thyroxine could not be demonstrated.
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