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  • Title: Immunological studies on urinary bladder tumors of rats and mice.
    Author: Taranger LA, Chapman WH, Hellström I, Hellström KE.
    Journal: Science; 1972 Jun 23; 176(4041):1337-40. PubMed ID: 5034547.
    Abstract:
    Human neoplasms derived from the same tissue have been previously shown to have tumor associated antigens characterizing that tissue type. Evidence is now presented for the existence of analogous antigens common to both rat bladder papillomas and carcinomas, and for antigens common to mouse bladder carcinomas. Rats immunized with syngeneic urinary bladder papillomas, then challenged with a methylcholanthrene pellet inserted into the bladder, develop (4 to 6 months later) fewer primary bladder tumors than rats immunized with normal bladder tissue.
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