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  • Title: A surface membrane determinant shared by subpopulations of thymocytes and B lymphocytes.
    Author: Stout RD, Yutoku M, Grossberg A, Pressman D, Herzenberg LA.
    Journal: J Immunol; 1975 Aug; 115(2):508-12. PubMed ID: 50365.
    Abstract:
    Utilizing a quantitative fluorescence assay with the fluorescence-activated cell sorter (FACS), we have demonstrated that a rabbit antiserum obtained by immunization with cells of a mouse IgM-producing plasma cell tumor (MOPC104E) is reactive with at least two surface determinants, designated Th-B and ML2, on subpopulations of normal murine lymphocytes. The ML2 determinant is restricted to B lymphocytes. The Th-B determinant is shared by splenic B lymphocytes and a large subpopulation of thymocytes, the latter of which express a 3-fold higher density of Th-B on their surface than do the B lymphocytes. Neither Th-B nor ML2 were found on peripheral T cells or on brain, liver, or kidney cells. The available evidence suggesting that Th-B may be a stem cell determinant that is lost upon maturation is discussed.
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