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  • Title: Lack of habituation of pain evoked potentials after naloxone.
    Author: Janicki P, Libich J, Gumułka W.
    Journal: Pol J Pharmacol Pharm; 1979; 31(3):201-5. PubMed ID: 503969.
    Abstract:
    Pain evoked potentials (EPs) were recorded in nucleus caudatus (NC) of rabbits after electric stimulation of the dental pulp. After 50--60 noxious stimuli the decrease in amplitude of evoked potentials occured. Naloxone, 1 mg/kg, temporarily abolished this effect and even after 350 noxious stimuli the habituation was not observed. On the other hand, naloxone did not affect the diminution of monosynaptic transcallosal potentials (TC--EP) evoked by repeated stimulation. It may be suggested that the habituation of EPs elicited by pain stimulation is due to endorphin release.
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