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  • Title: The mechanism of antigen-induced electrophoretic mobility reduction of guinea-pig macrophages.
    Author: Caspary EA.
    Journal: Clin Exp Immunol; 1972 Jun; 11(2):305-9. PubMed ID: 5040311.
    Abstract:
    The interaction of antigen with sensitized lymphocytes produces a protein substance capable of reducing the electrophoretic mobility of guinea-pig peritoneal macrophages. Reaction with the protein slowing factor also involves some vital synthetic activities of the macrophage. A critical number of lymphocytes is required to initiate the complete reaction suggesting that above this threshold recruitment may take place. It is suggested that the mechanism of action is a close parallel to that of macrophage migration inhibition.
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