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  • Title: The release of prostaglandins and rabbit aorta contracting substance (RCS) from rabbit spleen and its antagonism by anti-inflammatory drugs.
    Author: Gryglewski R, Vane JR.
    Journal: Br J Pharmacol; 1972 May; 45(1):37-47. PubMed ID: 5041506.
    Abstract:
    1. Slices of rabbit spleen generate rabbit aorta contracting substance (RCS) and a prostaglandin of the E series when they are vibrated or stirred.2. The release of both substances is increased by arachidonic acid and inhibited by aspirin-like drugs.3. When the spleen effluent containing RCS and prostaglandin E is incubated for a further 3 min, the prostaglandin concentration increases and the RCS concentration declines.4. RCS may therefore be an unstable intermediate in the biosynthesis of prostaglandins.
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