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  • Title: Double bond isomers of cloprostenol.
    Author: Bowler J, Brown ED, Crossley NS, Heaton DW, Lilley TJ, Rose N.
    Journal: Prostaglandins; 1979 Jun; 17(6):789-800. PubMed ID: 504688.
    Abstract:
    The syntheses of five compounds isomeric with the potent luteolytic agent cloprostenol are described. These are the trans-delta 5, cis and trans-delta 4, cis-delta 6 (methyl ester) and cis-delta 13 analogues. The cis-delta 4 isomer is as potent as cloprostenol as a luteolytic agent in hamsters but the others are markedly less so.
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