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  • Title: Pyruvate dehydrogenase activation in adipocyte mitochondria by an insulin-generated mediator from muscle.
    Author: Jarett L, Seals JR.
    Journal: Science; 1979 Dec 21; 206(4425):1407-8. PubMed ID: 505013.
    Abstract:
    Material in a chromatographic fraction from an extract of insulin-treated muscle stimulated pyruvate dehydrogenase activity in addipocyte mitochondria. This action was similar to insulin's activation of the enzyme in a plasma membrane-mitochondria mixture. Neither the chromatographic fraction nor insulin required adenosine triphosphate or magnesium ion (Mg2+), suggesting that both agents acted through a calcium-sensitive phosphatase. This fraction may contain a chemical mediator of insulin action.
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