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  • Title: [Toxicological characteristics of ampicillin].
    Author: Khosid GM, Shteĭnberg GB, Balabanova EL, Baru RV, Churagulova NK.
    Journal: Antibiotiki; 1975 Jun; 20(7):653-7. PubMed ID: 5051.
    Abstract:
    Toxocity of ampicillin trihydrate was studied in acute and chronic experiments. It was shown that the antibiotic had low acute toxicity, did not cumulate and had no skin-irritating effect. On its inhalation in concentrations of 5 mg/m3 for 4 months, ampicillin induced allergization of albino rats, decreased their immunity. The general toxic effect of the drug was slightly pronounced. Ampicillin in a concentration of 0.1 mg/m3 induced tension of the immunological reactivity of the organism. The maximum permissible concentration (MPC) of ampicillin in the working premises equal to 0.1 mg/m3 is recommended. Mark "Allergen" is necessary.
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