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  • Title: Long-term follow-up studies after homograft replacement of the mitral valve.
    Author: Graham AF, Schroeder JS, Daily PO, Harrison DC.
    Journal: Can Med Assoc J; 1972 Sep 23; 107(6):516-9. PubMed ID: 5057008.
    Abstract:
    Follow-up studies on 132 patients who have received fresh aortic homograft replacement of the mitral valve since May 1967 indicate good long-term function of the valve. Clinically the majority of patients are greatly improved and are free from the risks of long-term anticoagulant therapy. Hemodynamic studies performed on 13 patients at 25 to 41 months postoperatively showed a significant decrease in left atrial and pulmonary artery pressures with a small increase in cardiac output. Late deterioration of the homograft produced severe insufficiency in four cases and organic stenosis in two cases. Reasons for isolated deterioration are suggested.
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