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  • Title: Loss of the penicillinase plasmid after treatment of Staphylococcus aureus with sodium dodecyl sulfate.
    Author: Sonstein SA, Baldwin JN.
    Journal: J Bacteriol; 1972 Jan; 109(1):262-5. PubMed ID: 5057770.
    Abstract:
    Two strains of Staphylococcus aureus (PC1 and 196E), when grown in medium containing 0.002% sodium dodecyl sulfate (SDS), showed from 96.1 to 100% loss of the ability to produce penicillinase. Resistance to cadmium and zinc was lost concomitantly with the ability to produce penicillinase. A comparison of the rate of curing by SDS with the curing effects exerted by elevated temperature and ethidium bromide suggested that SDS is a more effective plasmid curing agent for susceptible strains of S. aureus than methods in use at present.
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