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  • Title: Fatty liver induction: inverse relationship between hepatic neutral lipid accumulation and dietary polyunsaturated fatty acids in orotic acid-fed rats.
    Author: Witting LA.
    Journal: J Lipid Res; 1972 Jan; 13(1):27-31. PubMed ID: 5059195.
    Abstract:
    The levels of hepatic neutral lipids in the orotic acid-fed rat were inversely related to the dietary levels of polyunsaturated fatty acids, as in the choline-deficient rat. Hepatic microsomal protein and phospholipid and total hepatic phospholipid were increased in orotic acid-induced fatty livers. The increase in phospholipid was largely restricted to the phosphatidylethanolamines.
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