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  • Title: Serum follicle-stimulating and luteinizing hormone and progesterone in single and multiple gestations following induction of ovulation.
    Author: Fogel M, Rubin BL, Ossowski R.
    Journal: Am J Obstet Gynecol; 1972 Mar; 112(5):629-39. PubMed ID: 5059593.
    Abstract:
    At the Mount Sinai School of Medicine in New York, researchers followed serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), and progesterone in 5 women treated with human menopausal gonadotropin (HMG) and human chorionic gonadotropin (HCG) for induction of ovulation. A total of 7 treatment cycles were followed. In 5 of the cycles conception occurred. Values in the 5 cycles in which conception occurred were dissimilar to values in normal menstrual cycles. Thus, efforts to mimic normal gonadotropin elaboration are probably unnecessary in the treatment of anovulatory women. Significant variation in values occurred among the patients. A midcycle FSH peak concomitant with the LH surge was clearly seen to be unnecessary for ovulation induction. Following ovulation a general decline in FSH occurred. FSH apparently was suppressed during the gestational period. In patients who had elevated pretreatment serum LH levels, LH apparently was suppressed during the first 1/2 of the HMG therapy; however, during the latter 1/2 of the HMG therapy, LH rose in these patients. Therapy-induced multiple ovulation with resultant multiple corpora lutea caused serum progesterone levels to rise to 2-3 times those of normal singleton gestations. Implantation appeared to have occurred 8-9 days after ovulation induction. The 5 pregnancies resulted in 3 term deliveries, 1 first-trimester spontaneous abortion, and a quadruplet premature delivery.
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