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  • Title: Uptake of antigen by human lymphocytes.
    Author: Merler E, Silberschmidt M.
    Journal: Immunology; 1972 May; 22(5):821-31. PubMed ID: 5063187.
    Abstract:
    Human lymphocytes were fractionated on gradients of bovine serum albumin (BSA). Cells obtained from the more dense layers bound antigen specifically. Cells capable of interacting with antigen contained antibody which was separable with the nuclear components of the cell. Immune cells contained antibody which was specific for the immunizing antigen. Cell-bound antibody mediated and, in the presence of isologous antibody, slightly enhanced the uptake of antigen. Specific antibody passively bound to cell membranes did not promote uptake of antigen. Antigen which bound to lymphocytes in vitro was not enzymatically digested within the cell but became bound to acid-insoluble nuclear DNA.
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