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  • Title: [The effect of aldosterone antagonists in juvenile heart surgery].
    Author: Wimmer M, Parth K, Holzer H.
    Journal: Acta Med Austriaca; 1979; 6(1):8-12. PubMed ID: 506658.
    Abstract:
    In children with congenital heart disease duration and extent of hyperaldosteronism and the influence of spironolactone after surgery with a heart-lung-machine, were evaluated by direct measurement of plasma aldosterone levels. Secondary hyperaldosteronism as seen in 11 patients without spironolactone-therapy after surgery did not persist very long. 14 children receiving spironolactone immediately after surgery showed an onset of drug efficacy at a period when plasma aldosterone in the group without spironolactone had begun to fall. As a practical consequence, spironolactone treatment should be initiated a few days prior to surgery in order to achieve full efficacy on the day of surgery.
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