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  • Title: Tiglicaciduria in propionicacidaemia.
    Author: Nyhan WL, Ando T, Rasmussen K, Wadlington W, Kilroy AW, Cottom D, Hull D.
    Journal: Biochem J; 1972 Feb; 126(4):1035-7. PubMed ID: 5073234.
    Abstract:
    Tiglic acid, which has not previously been found in human body fluids, was recently detected in the urine of two patients with propionicacidaemia. These patients had a documented defect in the oxidation of propionate. A competition between acrylyl-CoA and tiglyl-CoA for crotonase could explain the accumulation of tiglic acid.
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