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  • Title: Hemoglobin Lepore trait: globin synthesis in bone marrow and peripheral blood.
    Author: Gill F, Atwater J, Schwartz E.
    Journal: Science; 1972 Nov 10; 178(4061):623-5. PubMed ID: 5086396.
    Abstract:
    There was decreased synthesis of the beta-globin chain in the peripheral blood, and equal synthesis of alpha- and non-alpha-chains in the bone marrow of three patients with hemoglobin Lepore trait, similar to the findings in patients with heterozygous beta-thalassemia. There is a relative instability of the synthetic mechanism for normal beta-chain in these patients.
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