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  • Title: [Ganglioside composition of normal and leukemic bovine lymphocytes].
    Author: Diatlovitskaia EV, Zablotskaia AE, Volgin IuV, Azizov IuM, Bergel'son LD.
    Journal: Biokhimiia; 1979 Sep; 44(9):1623-9. PubMed ID: 508867.
    Abstract:
    The ganglioside composition of bovine peripheral lymphocytes was shown to change sharply under lymphoid leukemia. In normal lymph, lymph nodes, spleen and blood lymphocytes the major ganglioside is N-glycolylhematoside, whereas in calf thymus lymphocytes appreciable amounts of more polar components (GM1- and GD1a-like gangliosides) were found. In leukemic lymphocytes isolated from the same tissues the hematoside content is decreased, while the amount of more polar gangliosides is increased. Possible causes of the altered ganglioside pattern in leukemic lymphocytes are discussed.
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