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  • Title: Mechanism of hyperventilation in acute cerebrovascular accidents.
    Author: Lane DJ, Rout MW, Williamson DH.
    Journal: Br Med J; 1971 Jul 03; 3(5765):9-12. PubMed ID: 5091917.
    Abstract:
    Lumbar cerebrospinal fluid and arterial blood acid-base state were assessed in 19 patients within 24 hours of an acute cerebrovascular accident. Those with haemorrhage into the C.S.F. showed a lower C.S.F. pH and higher C.S.F. lactate than those without haemorrhage but the Pco(2), was similar in the two groups, suggesting that this greater C.S.F. acidity was not responsible for a greater degree of hyperventilation. In those without haemorrhage an inverse relation was found between C.S.F. pH and arterial Pco(2), suggesting that a non-chemical ventilatory drive-for example, due to central neurological damage-was responsible for the acid-base changes observed.
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